This paper focuses on aspects of energy flow and entropy in tumorigenesis and changes in the interaction between cancer cells and the host. A basic understanding of changes associated with tumorigenesis is needed to design and deploy novel and effective strategies for treating cancers. Another contributing factor is the genetic resistance mediated by genes encoding proteins such as ABC transporters. One contributing factor for impaired responses to chemotherapy is that only proliferating cells are affected by the action of chemotherapeutic drugs (kinetic resistance of tumors). The treatment failures are, at least in part, due to tumor cell resistance to chemotherapeutics. Bergmann-LeitnerĪbstract: Chemotherapy can result in partial or temporary remission, but often does not completely eradicate cancer. Thornton, Annamaria Molnar, Dezso Gaal, Liaofu Luo and Elke S. Title: Thermodynamic Aspects of Cancer: Possible Role of Negative Entropy in Tumor Growth, its Relation to Kinetic and Genetic ResistanceĪuthor(s): Joseph Molnar, Barry S. Keywords: cancer cells, entropy, thermogenesis, tumor growth, drug resistance ![]() We propose that correlating those changes with the progression of tumors will assist in the design and deployment of novel and more efficacious strategies for chemotherapy and combined therapies. ![]() Chemotherapy can result in partial or temporary remission, but often does not completely eradicate cancer.
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